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pentobarbital raises toxicity of ifosfamide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe. CYP3A4 inducers may well increase the metabolism of ifosfamide to its active alkylating metabolites.pentobarbital will minimize the extent or impact of buprenorphine subdermal implant by affecting hepatic/intestinal enzyme CYP3